FSL0499

Structure

• InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChIKey=YPHMISFOHDHNIV-FSZOTQKASA-N

Synonyms

• 66-81-9
• A-67
• Acti-Aid
• Actidione
• Cycloheximide
• Cycloheximide
• D-73-2
• GS-700-II
• Naramycin
• Naramycin-A
• NSC-185
• P-42-A
• Zygomycin-D

Origin

Streptomyces griseus

Biological activities

Inhibition of eukariotic protein synthesis

Therapeutic

Anticancer
Antifungal

Target

60S ribosomes

Assay information

Inhibitor of protein synthesis in eukaryotes, and works as an antifungal antibiotics
Reduction of the context of total nuclear ribonucleoprotein complexes at non-lethal dose of rat liver (2 mg/kg body weight)
Inhibitor of protein synthesis in rat liver (2-5 mg/kg body weight)
Inducer of apotosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and other cell types
Inhibitor of hFKBP12, peptidyl-prolyl isomerase (PPIase) (K_i = 3.4 μM)
Binding to the tRNA E-site of the 60S subunit