FSL0909
- Structure
- InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
- InChIKey=OFVLGDICTFRJMM-WESIUVDSSA-N
- Synonyms
-
- 60-54-8
- Achromycin (chloride)
- Economycin (chloride)
- MS0A0383
- Tetracycline
- Tetracycline
- Origin
- Streptomyces sp.
- Biological activities
- Inhibition of bacterial protein synthesis
- Therapeutic
-
Antibacterial
- Target
-
30S ribosomal subunit
- Assay information
-
A short-acting antibiotic that inhibits bacterial growth by inhibiting translation through the bindind to the 30S ribosomal subunit (Kd=1-20 μM) and preventing the amino-acyl tRNA from binding to the A site of the ribosome
Alteration of the cytoplasmic membrane of bacteria causing leakage of intracellular contents, such as nucleotides, from the cell. Passively diffuse through porin channels in the bacterial membrane
Multiple mechanisms of actions to be beneficial for the patients suffering from various pathology