(+)-Bicuculline
- Structure
- InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
- InChIKey=IYGYMKDQCDOMRE-ZWKOTPCHSA-N
- Synonyms
-
- Origin
- Adlumia fungosa
Capnoides sempervirens
Corydalis govaniana
Dicentra cucullaria
- Biological activities
- GABAA antagonist
- Therapeutic
-
Antidepressant
Antiepileptic
- Target
-
GABAa receptor channels
SK channels
- Assay information
-
Antagonistic activity against [3H]GABA binding to hepatocytes (IC50 = 50 μM)
Blocking activity against SK (small-conductance calcium-activated potassium) channels: IC50 of 46.3 μM for SK1, and of 63.3 μM for SK2 at -60 mV
Inhibitor of [3H]muscimol binding on spinal cord (IC50 = 16 μM), brain (IC50 = 5 μM), and cultured neurons (IC50 = 5 μM)