NPEdia

(+)-Bicuculline

Structure
(+)-Bicuculline
Synonyms
Origin
Adlumia fungosa
Capnoides sempervirens
Corydalis govaniana
Dicentra cucullaria
Biological activities
GABAA antagonist
Therapeutic
Antidepressant
Antiepileptic
Target
GABAa receptor channels
SK channels
Assay information
Antagonistic activity against [3H]GABA binding to hepatocytes (IC50 = 50 μM)
Blocking activity against SK (small-conductance calcium-activated potassium) channels: IC50 of 46.3 μM for SK1, and of 63.3 μM for SK2 at -60 mV
Inhibitor of [3H]muscimol binding on spinal cord (IC50 = 16 μM), brain (IC50 = 5 μM), and cultured neurons (IC50 = 5 μM)