FSL0879

Structure

• InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)
• InChIKey=UCSJYZPVAKXKNQ-UHFFFAOYSA-N

Synonyms

• 57-92-1
• Streptomycin
• Streptomycin-A

Origin

Streptomyces griseus

Biological activities

Inhibition of bacterial protein synthesis

Therapeutic

Antibacterial
Antituberculosis

Target

30S ribosomal protein S12

Assay information

Binding to ribosomal protein S12, a 30S subunit of the bacterial ribosome, causing protein synthesis inhibition
Antibacterial activity against Gram-(+) strains (MIC [μg/ml]: S. aureus, 0.125; B. subtilis, 0.25; E. coli, 1.0; P. aeruginosa, 0.5; M. kansasii, 3.13; M. intracellulare, 12.5)
Inhibition of the binding of the Tat protein to mRNA with IC₅₀ of 9.5 μM