FSL0932

Structure

• InChI=1S/C22H29NO5/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5/h8-14H,7,15H2,1-6H3
• InChIKey=LORDFXWUHHSAQU-UHFFFAOYSA-N

Synonyms

• 39133-31-8
• Trimebutine

Origin

Chemically synthesized

Biological activities

Gastrointestinal peptides releasing (motilin)
Modulation of peptides (vasoactive intestinal peptide, gastrin , glucagon)
Opiate agonist (peripheral) μ, κ, δ

Therapeutic

Antimuscarinic

Target

Opiate receptors

Assay information

Inhibitory Effect on electrically evoked contraction (IC₅₀ [μM]) : Guinea-pig ileum (4.7±0.2), Mouse vas deferens (21±2), Rabit vas deferens (>gt; 100 μM)
[³H]batrachotoxin binding displacement. (K_i = 2.66±0.15 μM)
Currents block in sensory neurons: Sodium currents (IC₅₀ = 0.83±0.09 μM), Calcium currents (no effect), Potassium currents (23±6% block at 10 μM)