FSL0404

Structure

• InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
• InChIKey=VKJGBAJNNALVAV-UHFFFAOYSA-M

Synonyms

• (-)-Berberine chloride

Origin

Berberis sp.

Biological activities

Wide range of pharmacological activities.

Therapeutic

Antibacterial
Anticancer
Antidiabetes
Antifungal
Antiinflammation
Antiviral

Target

RNA transcription
Kinase inhibition

Assay information

Antifungal activity: MIC =1 μg/mL
Nasopharyngeal Carcinoma Ezrin Phosphorylation (Rho Kinase Ki=0.35 μM)
Adipocyte differentiation (CREB Transcriptional Activity)
Berberine inhibits proliferation of various cancer cell types (IC₅₀ = 30-100 μM)