FSL0393

Structure

• InChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)
• InChIKey=RIOXQFHNBCKOKP-UHFFFAOYSA-N

Synonyms

• 17804-35-2
• Benomyl

Origin

Chemically synthesized

Biological activities

Inhibition of microtubule polymerization

Therapeutic

Antifungal

Target

β-Tubulin

Assay information

Fungi show large variations in sensitivity to benomyl. Based on sensitivity to benomyl, fungi can be classified into four categories, resistant (ED50 >gt;100 μg/ml), tolerant (ED50 = 10-100 μg/ml), sensitive (ED50 = 1-10 μg/ml), a
Inhibition of microtubule polymerization of bovine brain tubulin in vitro (IC₅₀: 58.3 μM)
Inhibition of HeLa cell proliferetion (IC₅₀: 5 μM) and the cell cycle progression during mitosis (IC₅₀: ca 15 μM)