FSL0945

Structure

• InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2/t16-,17-/m1/s1
• InChIKey=YSSBJODGIYRAMI-IAGOWNOFSA-N

Synonyms

• (+/-)-Vesamicol hydrochloride
• 120447-62-3

Origin

Chemically synthesized

Biological activities

Inhibition of acetylcholine transport

Therapeutic

Molecular beacon for a cholinergic marker

Target

Vesicular acetylcholine transporter (VAChT)

Assay information

Vesamicol binds tightly (Ki: 41 nM) to VAChT and inhibits transport of acetylcholine noncompetitively
(+/-)-Vesamicol inhibits in vitro acetylcholine storage (IC₅₀: 40 nM), and shows acute toxicity in mice (LD₅₀: 16 μmol/kg)
(-)-Vesamicol is more biologically active than (+)-vesamicol