FSL0350
- Structure
- InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
- InChIKey=ITPDYQOUSLNIHG-UHFFFAOYSA-N
- Synonyms
-
- 1951-25-3
- Amiodarone hydrochloride
- Origin
- Chemically synthesized
- Biological activities
- The class III antiarrhythmic action partly through blockade of multi channels
- Therapeutic
-
Antiarrhythmic (class III)
Vasodilator
- Target
-
Multi channels (K+, Na+, Ca2+)
PTX-sensitive G protein
- Assay information
-
Blockage of multi channels (IC50 [μM]): ICaL (0.4-5.8), ICaT (2.4), INa (0.1-7.3), IK (6.3), IKNa (1.0), Ito (4.9), IKAch (2.0), IKATP (2.3), INa/Ca (3.3)
Activation of GTPase of reconstituted Gi/Go and Gi2 with EC50 values of 20 μM and 50 μM
Cytotoxicity against PANC1, H9C2, BRL-3A (GI50: 10-50 μM)
Antifungal activity against Heterobasidiomycetes, Ascomycetes, and Hyphomycetes (MIC50: 1-10 μM)