FSL0723

Structure

• InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
• InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Synonyms

• 50-65-7
• niclosamide

Origin

Chemically synthesized

Biological activities

Inhibition of mitochondrial oxidative phosphorylation of parasitic helminths
Inhibition of Wnt/β-catenin signaling

Therapeutic

Anthelmintic
Antiparasitic

Target

Unknown

Assay information

Works by killing tapeworms on contact. Adult worms are rapidly killed, presumably due to uncoupling of oxidative phosphorylation
Anticancer activity (IC₅₀ less than 1 μM for prostate PC-3 and DU145 and breast MDA-MB-231 and T-47D cells)
Antiviral activity (suppresses LRP6 expression and phosphorylation, blocks Wnt3A-induced β-catenin accumulation, inhibiting Wnt/β-catenin signaling
Inhibits gram-negative pathogen Pseudomonas aeruginosa quorum sensing
Targets acidic endosomes with broad antiviral effects