FSL0608

Structure

• InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3
• InChIKey=MFZWMTSUNYWVBU-UHFFFAOYSA-N

Synonyms

• 3105-97-3
• Hycanthone

Origin

Chemically synthesized

Biological activities

Inhibition of DNA repair

Therapeutic

Anticancer
Antischistosomiasis

Target

Apurinic endonuclease-1 (APE1)

Assay information

Schistosomicidal activity for experimentary schistosoma infected hamsters (ED50: 0.78 mg/kg, per os)
Antitumor activity for P388 lymphocytic leukemia-bearing mice
Inhibition of APE1 endonuclease activity by direct binding to the hydrophobic site (K_d = 10 nM)