FSL0422

Structure

• InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18?,19-,21-,22?,23+/m0/s1
• InChIKey=RRKTZKIUPZVBMF-PLNGPGDESA-N

Synonyms

• 357-57-3
• Brucine

Origin

Strychnos
Strychnos nux-vomica

Biological activities

Glycine receptors brocker
Inducion of apoptosis
Inhibition of COX-2 gene expression
Paralyzes inhibitory neurons

Therapeutic

Anticancer

Target

NF-κB

Assay information

Cytotoxic effect (IC₅₀ [mM]): HepG2 (0.32), Vero (0.622), MCF-7 (0.48), HL-60 (0.107)
DNA re-replication in SW480 colon adenocarcinoma cells (IC₅₀ = 0.41 μM)