FSL0392

Structure

• InChI=1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H
• InChIKey=NLOALSPYZIIXEO-UHFFFAOYSA-N

Synonyms

• 23602-78-0
• Benfluorex hydrochloride

Origin

Chemically synthesized

Biological activities

Activate the nuclear receptor transcription factor HNF4a

Therapeutic

Anorectic
Antihyperglycemic
Hypolipidemic

Target

HNF4a

Assay information

Used to treat hyperlipidemia and type II diabetes, induction of the reduction in cofactor availability (acetyl-CoA, NADH, and ATP) as the result of the inhibition of β-oxidation
Inhibition of hepatic lipogenesis and triglyceride and sterol synthesis
Hit compoudns in the human insulin promotor lipotoxicity reversal screen using T6PNE cells (EC50 = 24.4 μM)
Interaction with and activation of HNF4α directly shown by DARTS experiment