FSL0924

Structure

• InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
• InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N

Synonyms

• 2398-96-1
• Tolnaftate

Origin

Chemically synthesized

Biological activities

Inhibition of microsomal squalene epoxidase in ergosterol biosynthesis
Selectively active against dermatophytes

Therapeutic

Antifungal

Target

Squalene epoxidase

Assay information

Antimicrobial activity (MIC [μg/ml]): T. int. (Inhibition of squalene epoxidase (IC₅₀ [nM]): T.rubrum enzyme (51.5), C. albicans enzyme (1040)