FSL0522

Structure

• InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27?,28?,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
• InChIKey=WDJUZGPOPHTGOT-KSVSUYAUSA-N

Synonyms

• 71-63-6
• Digitoxin
• MS0A0139

Origin

Digitalis purpurea

Biological activities

Na⁺/K⁺ ATPase membrane pump inhibition

Therapeutic

Antiarrhythmic
Cardiotonic

Target

Na⁺/K⁺-ATPase

Assay information

Na⁺/K⁺ ATPase inhibition (2.8 μM)
The antiproliferative and apoptotic effects in several cancer cell lines: NCI-H460 cells, IC₅₀ = 49.8 nM