NPL70571-01
- Structure
- InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
- InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N
- Synonyms
-
- 64-86-8
- colchicine
- FSL0480
- MS0A0105
- NP-010664
- NP1114
- Origin
- Colchicum autumnale
- Biological activities
- Inhibition of microtubule polymerization
- Therapeutic
-
Anticancer
- Target
-
Tubulin beta-1 chain
- Assay information
-
Inhibition of microtubule polymerization (IC50 = 3.2 μM)
Growth inhibition against cancer cells (MCF7; 13 nM)
Inhibition of mitosis (>gt; 50 nM)
Inhibition of human trophoblast differentiation (2.5 - 250 μM)