FSL0316

Structure

• InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
• InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N

Synonyms

• 59-66-5
• Acetazolamide

Origin

Chemically synthesized

Biological activities

Inhibition of carbonic anhydrase

Therapeutic

Antiglaucoma
Diuretics

Target

Carbonic anhydrase

Assay information

human carbonic anhydrases (CAII, IV, IX etc.): K_i =2.5-250 nM
Invasion of renal cancer cells (Caki-1, Caki-2, ACHN, and A-498, invasion rate 18-74% at 10 μM)
Cell proliferation in pancreatic cancer cells (AsPC-1 and PANC-1) at 100 μM