FSL0358
- Structure
- InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
- InChIKey=YKJYKKNCCRKFSL-RDBSUJKOSA-N
- Synonyms
-
- 22862-76-6
- Ahygroscopin-A
- Anisomycin
- Flagecidin
- NSC-76712
- PA-106
- SA-3097
- Origin
- Streptomyces sp.
- Biological activities
- Inhibition of protein synthesis
- Therapeutic
-
Antifungal
- Target
-
60S ribosomal subunit
- Assay information
-
Inhibition of protein synthesis in vitro using yeast ribosome by binding to 60S ribosomal subunits and blocking peptide bond formation (IC50 = 1 μM)
Preventing elongation of peptide and causing polysome stabilization
Activation of the stress kinases SAPK/JNK and p38 MAPK, as well as p70/85 S6 kinase in mammalian cells, which results in the rapid induction of immediate-early (IE) genes, such as c-fos, fosB, c-jun, JunB, and JunD at a dose of 25 ng/mL, le
Potent signaling agonist, synergizing with growth factors and phorbol esters to superinduce these IE genes
Induction of apoptosis in many cancer cell lines U937 (1 μg/mL) and PC12 cells (10 ng/mL)