FSL0732

Structure

• InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
• InChIKey=KYRVNWMVYQXFEU-UHFFFAOYSA-N

Synonyms

• 31430-18-9
• FSL0732
• Nocodazole

Origin

Chemically synthesized

Biological activities

antineoplastic
Inhibition of microtubule polymerization

Therapeutic

Anticancer

Target

Tubulin

Assay information

Nocodazole exhibits anticancer activity and is also widely used in cell biology research as a tool for synchronization of the cell division cycle. Mechanistically, nocodazole binds to tubulin with apparent K_a of (4±1) x105
It caused the Golgi apparatus dispersion in mammalian fibroblast cells
It exhibits inhibitory activity of cell division in HeLa cells (IC₅₀: 22 nM)
It induces apoptosis in HCT116 cells (fully effective concentration: 200 ng/ml)