FSL0431

Structure

• InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5?,6?,9-,10+
• InChIKey=DHZBEENLJMYSHQ-OBDNUKKESA-N

Synonyms

• 56-25-7
• Cantharidin

Origin

Epicauta
Lytta vesicatoria

Biological activities

Inhibition of protein phosphatase 2A

Therapeutic

Anticancer

Target

Protein phosphatase 2A (PP2A)

Assay information

IC₅₀ of phosphorylase a phosphatase activity of PP2A AC form (EC 3.1.3.16) by cantharidin and okadaic acid treatment are 50 nM and 12 nM, respectively
Inhibition of purified catalitic subunits of PP2A (IC₅₀=0.16 μM by cantharidin and 0.04 nM by okadaic acid) and PP1 (IC₅₀=1.7 μM by cantharidin)
Growth inhibition (IC₅₀) of human pancreatic cancer cells (PANC-1 and CFPAC-1) at 72 h after cantharidin treatment are 9.42 and 7.25 μM, respectively. In comparison, the IC₅₀ of normal human pancreatic dust cells is