FSL0429
- Structure
- InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
- InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N
- Synonyms
-
- 7689-03-4
- Camptothecin
- Camptothecin
- Origin
- Camptotheca acuminata
- Biological activities
- antineoplastic
Inhibition of DNA synthesis
- Therapeutic
-
Anticancer
- Target
-
Topoisomerase I
- Assay information
-
Stabilization of the cleavable complex formed between DNA and topoisomerase I, preventing DNA re-ligation and causing DNA synthesis inhibition
Growth inhibition against various cancer cell lines (9KB, HL-60, L1210, MOLT4, KG1 at 0.01-0.1 μg/ml)