FSL0949

Structure

• InChI=1S/C16H22N2O2S/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16/h3-4,7-11,18H,1-2,5-6,12-13,17H2
• InChIKey=FVJRBJIENDRNBE-UHFFFAOYSA-N

Synonyms

• 61714-27-0
• N-(6-aminohexyl)-1-naphthalene sulfonamide

Origin

Chemically synthesized

Biological activities

Calmodulin antagonist that binds to calmodulin and inhibits Ca²⁺-calmodulin-regulated activities, including phosphodiesterase activation and myosin light chain kinase

Therapeutic

Vasodilator

Target

Calmodulin

Assay information

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) at 30 μM produced an external ATP-dependent permeability change in CHO cells at pH 8.2. The drugs also significantly reduced the cellular ATP concentrationat the alkaline pH
32 μM of W-7 suppressed 50% of CHO-K cell proliferation, while 200 μM of W-5 was required for similar activity