FSL0680
- Structure
- InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)
- InChIKey=WZNJWVWKTVETCG-UHFFFAOYSA-N
- Synonyms
-
- 500-44-7
- L(-)-Mimosine
- L-Mimosine from Koa hoale seeds
- Origin
- Leucaena leucocephala
Mimosa pudica
- Biological activities
- Inhibition of DNA replication and cell cycle arrest at G1
- Therapeutic
-
DNA synthesis inhibitor
- Target
-
Iron/zinc chelation
Serine methyltransferase
Deoxyhypusyl hydroxylase
- Assay information
-
Cell growth inhibition of lung cancer cells by 40-60% at 400 μM
Cell growth inhibition of brest cancer cells by more than 90% at 400 μM
Inhibition of the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1)
Inhibition of deoxyhypusyl hydroxylase (50 μM)
Inhibition of tyrosinase (IC50=3.68 μM)
Inhibition of the binding of Ctf4 to chromatin