FSL0754
- Structure
- InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17?,18+,19+,21?,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1
- InChIKey=LPMXVESGRSUGHW-XPXORLBYSA-N
- Synonyms
-
- (-)-Ouabain
- 11018-89-6
- MS0A0456
- ouabain
- Origin
- Acokanthera oubaio
Strophanthus gratus
- Biological activities
- An increase in intracellular sodium and calcium concentrations
- Therapeutic
-
Cardiotonic
- Target
-
Sodium/potassium-transporting ATPase
- Assay information
-
Inhibition of human Na+/K+-ATPase α1β1 (Kd = 13.3 ± 5.2 nM), α2β1 (Kd = 32.8 ± 15.7 nM), α3β1 (Kd = 16.7 ± 1.8 nM)
Induction for the apoptosis in MDA-MB-231 breast cancer cells by increasing free calcium concentration and by activating caspase-3 (IC50 = 150 nM (24h), 90 nM (48 h))
Antiproliferative and apoptotic effects in several cancer cell lines, including 1. Small cell lung cancer cell: H69 AR (IC50 = 45 nM, MRP-associated resistance), NCl-H69 (IC50 = 70 nM, parental resistance); 2. Histiocy
Cytoprotective effects of cardiac glycosides in human tumor cell at the low concentrations (0.1-10 nM)