FSL0578

Structure

• InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+/m1/s1
• InChIKey=BRZYSWJRSDMWLG-DJWUNRQOSA-N

Synonyms

• G-418

Origin

Micromonospora echinospora

Biological activities

Inhibition of protein synthesis

Therapeutic

Antibacterial
Antiprotozoal
Coccidiostats

Target

80S ribosomes

Assay information

Effective inhibition of wheat-germ, cell-free translation programmed with rat-liver polydenylated RNA (Leading to aberrant protein synthesis in both prokaryotic and eukaryotic cells (IC₅₀ of translation inhibition for Eukaryotic system = 2.0 μM ± 0.3 μM, for Prokaryotic system = 8.9 ± 1.5 nM)
Exhibition of antibacterial activity against B. subtilis (MIC Toxicity for HEK-293, human embryonic kidney cell, LC50 = 1.3 ± 0.1 mM
Inhibition of leishmania promastigotes in the low micromolar range: L. major (LC50 = 1.95 ± 0.05 μM), L. donovani (LC50 = 5.8 ± 0.9 μM)
Fungal growth inhibition of Fusarium graminearum and F. culmorum (MIC = 25 μg/mL in PDA for each, 10 days)