FSL0551
- Structure
- InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11?,15?,20-,21-,22+,24-,25-,26?,27-,29?/m1/s1
- InChIKey=VJJPUSNTGOMMGY-GEGAHKOSSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- antineoplastic
Induction of DNA damage
- Therapeutic
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Anticancer
- Target
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Topoisomerase II (TOP-2)
- Assay information
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Inhibition of TOP-2 activity (MIC = 0.1 μM)
Induction for accumulation of Phosphorylated histone H2AX, a hallmark of DNA double- strand breaks in cells, in HeLa cells (10 μM)
Induction of apoptosis in cancer cells: HL-60, U937 and A549 (IC50: 0.25 ± 0.04, 0.92 ± 0.24 and 5.9 ± 1.7 μM)
Induction of DNA cleavage complex formation due to the interaction with D-ring of etoposide
Treating fibrosarma in tumor-bearing mice using etoposide entrapped camel milk phospholipids liposomes