NPEdia

FSL0551

Structure
FSL0551
Synonyms
Origin
Chemically synthesized
Biological activities
antineoplastic
Induction of DNA damage
Therapeutic
Anticancer
Target
Topoisomerase II (TOP-2)
Assay information
Inhibition of TOP-2 activity (MIC = 0.1 μM)
Induction for accumulation of Phosphorylated histone H2AX, a hallmark of DNA double- strand breaks in cells, in HeLa cells (10 μM)
Induction of apoptosis in cancer cells: HL-60, U937 and A549 (IC50: 0.25 ± 0.04, 0.92 ± 0.24 and 5.9 ± 1.7 μM)
Induction of DNA cleavage complex formation due to the interaction with D-ring of etoposide
Treating fibrosarma in tumor-bearing mice using etoposide entrapped camel milk phospholipids liposomes