FSL0803
- Structure
- InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
- InChIKey=YJGVMLPVUAXIQN-XVVDYKMHSA-N
- Synonyms
-
- 518-28-5
- podofilox
- Podophyllotoxin
- Origin
- Podophyllum peltatum
- Biological activities
- antineoplastic
Inhibition of tubulin polymerization
- Therapeutic
-
Anticancer
- Target
-
Tubulin
Topoisomerase II
- Assay information
-
Treat of SV40 virusinfected BSC cells at various times postinfection by VM-26, podophyllotoxin derivertive (100 μM, 20 min)
Accumulation of metaphase (Kmet) for total of 50% of the cells (approximately 30 nM, peak of maximal metaphase accumulation = 100 nM)
Decrease of the ratio of cells in anaphase to cells by metaphase in a concentration-dependent manner, (50% decrease = 5 nM (Kana/met))
Zero of the anaphase/metaphase ratio (33 nM). Half-maximal inhibition of cell division (Kdiv) (IC50 = 20 nM)
Model compound in structure-activity relationship study because of a large number of semisynthetic derivatives