FSL0784
- Structure
- InChI=1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6?,7-,8?,9?,10+,13+,14+,15-/m0/s1
- InChIKey=PIMZUZSSNYHVCU-LJGWEWMTSA-N
- Synonyms
-
- Origin
- Biological activities
- A noncompetitive antagonist at GABA receptors
- Therapeutic
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CNS stimulant
- Target
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GABA-A receptors
- Assay information
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Inhibition of tiagabine-elicited depolarizations (100 μM) as the GABAa receptor antagonist
A potent antagonist of GABA receptors (IC50: 237 nM) at synapses in central nervous system
Inhibition of 35S-t-buthylbicyclophosphoro-thionate binding to the Cl-channel (IC50: 1.7 μM)