FSL0902

Structure

• InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
• InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N

Synonyms

• 129-46-4
• Suramin

Origin

Chemically synthesized

Biological activities

Inhibition of catalytic activity of topoisomerase II

Therapeutic

Anticancer
Antifiliarial
Antitrypanosomal

Target

Topoisomerase II

Assay information

Inhibition of yeast topoisomerase II with IC₅₀ value of 5 μM without stabilization of the covalent DNA-topoisomerase II reaction intermediate