FSL0760

Structure

• InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20-,21+,22+,23+/m1/s1
• InChIKey=YKRGDOXKVOZESV-MRPXEQBUSA-N

Synonyms

• 23180-57-6
• FSL0760
• Paeoniflorin

Origin

Paeonia lactiflora

Biological activities

Inhibition of inflammatory responses
inhibition of oxidative stress and Ca²⁺ overload

Therapeutic

Analgesic
Antiallergic
Antidepressant
Antihyperglycemia
Antiinflammatory

Target

Intercellular adhesion molecule-1 (ICAM-1)

Assay information

Delayed protection in mice (50, 100 mg/kg) from lipopolysaccharide (LPS)-induced acute lung injury (ALI) by alleviating inflammatory cell infiltration and microvascular permeability
Inhibition of proinflammatory cytokine expression through down-regulating the activation of p38 MAPK, JNK, and NF-kB playing an important role in the action of paeoniflorin
Delayed protection in the ischemia-injured rats (5 mg/kg) decreasing infarct volume (250.1 ± 17.2% mm3 - 106.0 ± 11.7% mm3) via inhibiting MAPKs/NF-kB-mediated inflammatory responses
Protection against glutamate-induced apoptotic cell death in PC12 cells (1, 10, 50 μM, viability increasing from 80, 88 and 92% of the control value). The protective effect is mediated by antioxidant mechanisms and Ca²⁺ antago
Inhibition of the ICAM-1 expression level elevated in LPS-induced U937 cells and TNF-α-stimulated human umbilical vein endothelial cells by utilizing RT-PCR
Inhibition of dextran sulface sodium (DSS)-induced activation for ERK1/2, JNK and p38 MAPKs
Inhibition of 2,2'-azinobis-(3-thylbenzothiazoline-6-sulfonic acid) formation, which is a substrate of peroxidase (IC₅₀ = 419.7 μM)
Increase of advanced glycation end product-induced glutathione peroxidase and catalase activities (10-8-10-4 M, pretreatment)