FSL0588

Structure

• InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
• InChIKey=BOVGTQGAOIONJV-UHFFFAOYSA-N

Synonyms

• 21187-98-4
• Gliclazide

Origin

Chemically synthesized

Biological activities

Insulin secretion

Therapeutic

Antidiabetic

Target

Sulfonylurea receptors (SUR-1)

Assay information

Block of KATP channels in pancreatic beta-cells (IC₅₀ = 184 ± 30 nM), cardiac myocytes (IC₅₀ = 19.5 ± 5.4 μM) and arterial smooth muscle (IC₅₀ = 37.9 ± 1.0 μM) isolated from Mouse
Reduction in the blood glucose level on alloxan induced diabetic Albino Wistar rats fed with pellet contaied 2% gliclazide
Biphasic reduction of blood glucose levels in normal and diabetic rats with maximum activity attained at 2h and 8h, and hypoglycemic activity for rabbits (Max: 4h post dose)
Marked reduction of blood glucose levels in rats/rabbits in combination with aminodarone