FSL0326

Structure

• InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
• InChIKey=VGZSUPCWNCWDAN-UHFFFAOYSA-N

Synonyms

• 968-81-0
• Acetohexamide
• Dymelor

Origin

Chemically synthesized

Biological activities

Increasing insulin release from the beta cells in the pancreas

Therapeutic

Antidiabetes (diabetes mellitus type 2)
Hypoglycemic agent

Target

ATP-sensitive inward rectifier potassium channel 11 (Sulfonylurea receptor 1, Kir 6.2)

Assay information

Blocking activity against sulfonylurea receptor 1, Kir 6.2
Inhibitor of [³H]glibenclamide (IC₅₀ = 330 μM)
Binding to human serum albumin (HSA) with high affinity binding site (K_a = 1.3 (± 0.2) × 105 M^-1) and low binding site (K_a = 3.5 (± 3.0) × 102 M^-1)