NPEdia

FSL0833

Structure
FSL0833
Synonyms
Origin
Rauvolfia serpentina
Biological activities
Inhibition of vesicular uptake of neurotransmitters, catecholamine and serotonin
Therapeutic
Antihypertensive
Antipsychotic
Target
Vesicular monoamine transporter (VMAT)
Assay information
Binding to VMAT with high affinity (Kd = 30 pM)
Inhibitor of [3H] dopamine uptake in cromaffin granuels (IC50 = 37 nM)
Inhibitor of [3H] norepinephrine transport (IC50 = 9.5 nM) (Kiap = 4.8 μM)
Inhibitor of vesicular monoamine transporter