FSL0833
- Structure
- InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
- InChIKey=QEVHRUUCFGRFIF-MDEJGZGSSA-N
- Synonyms
-
- Origin
- Rauvolfia serpentina
- Biological activities
- Inhibition of vesicular uptake of neurotransmitters, catecholamine and serotonin
- Therapeutic
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Antihypertensive
Antipsychotic
- Target
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Vesicular monoamine transporter (VMAT)
- Assay information
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Binding to VMAT with high affinity (Kd = 30 pM)
Inhibitor of [3H] dopamine uptake in cromaffin granuels (IC50 = 37 nM)
Inhibitor of [3H] norepinephrine transport (IC50 = 9.5 nM) (Kiap = 4.8 μM)
Inhibitor of vesicular monoamine transporter