FSL0620

Structure

• InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
• InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N

Synonyms

• 113-52-0
• Imipramine

Origin

Chemically synthesized

Biological activities

Inhibition of the neuronal reuptake of neurotransmitters, noradrenaline and serotonin

Therapeutic

Antidepressant

Target

Sodium-dependent noradrenaline transporter (NET)
Sodium-dependent serotonin transporter (5HTT)

Assay information

Inhibitor of serotonin transporter (K_d = 1.4 nM) and noradrenaline transporter (K_d = 37 nM)
Inhibitor of dopamine transporter (K_d = 8.5 μM)
Reduce human HT29 colon carcinoma cell viability (IC₅₀ = 53 μM)