FSL0616

Structure

• InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
• InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N

Synonyms

• 15687-27-1
• Ibuprofen

Origin

Chemically synthesized

Biological activities

Inhibition of the COX-dependent formation of PGH2

Therapeutic

Nonsteroidal antiinflammatory

Target

COX-1
COX-2

Assay information

Inhibitor of prostanoid formation determined in the COX-1 (IC₅₀ = 7.6 μM) and COX-2 (IC₅₀ = 7.2 μM)
S-ibuprofen: Inhibitor of PGHS-1 (IC₅₀ = 2.1 μM) and PGHS-2 (IC₅₀ 1.6 μM)
R-ibuprofen: Inhibitor of PGHS-1 (IC₅₀ = 34.9 μM)
R-ibuprofen: No inhibitor activity against PGHS-2
Binding to amyloid beta fibrils: K_i = 11.3 nM