FSL0407
- Structure
- InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16?,17-,19-,20-,21-,22-/m0/s1
- InChIKey=UREBDLICKHMUKA-REKGUKDCSA-N
- Synonyms
-
- 378-44-9
- Betamethasone
- Celestone
- Origin
- Chemically synthesized
- Biological activities
- Function as a potent glucocorticoid steroid
- Therapeutic
-
Antiinflammatory
Immunosuppressive
- Target
-
Glucocorticoid receptor
- Assay information
-
Glucocorticoid receptor agonist (Kd = 8.31 nM)
Antiinflammatory activity (IC50 = 1.4 μg/ml)
Inhibition of basal phospholipase A2 activity (IC50 = 1.4 μg/ml)
Synegistic effect of caffeine and betametasone on expression of surfactant protein B (SP-B) mRNA