FSL0622
- Structure
- InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
- InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Inhibition of the COX-dependent formation of prostaglandin precursors
- Therapeutic
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Antiinflammatory
Antipyretic
- Target
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COX-1
COX-2
Phospholipase A2 (PLA2)
- Assay information
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Inhibitor of phospholipase A2 (IC50 = 145 mM)
Inhibitor of the enzymatic activities of COX-1 (IC50 = 0.01 μg/ml) and COX-2 (IC50 = 0.6 μg/ml)
Inhibitor of the enzymatic activities of hCOX-1 (IC50 = 0.08 mM) and hCOX-2 (IC50 = 0.96 mM)
Inhibitor of the production of prostaglandins
Inducer of differentiation of C3H10T1/2 cells to adipocytes through binding to PPARγ (EC50 = approximately 80 μM)