FSL0806

Structure

• InChI=1S/C17H23N5O14/c18-5(7(24)4(23)2-35-16(19)33)12(28)20-6(15(31)32)10-8(25)9(26)13(36-10)22-1-3(14(29)30)11(27)21-17(22)34/h1,4-10,13,23-26H,2,18H2,(H2,19,33)(H,20,28)(H,29,30)(H,31,32)(H,21,27,34)/t4-,5-,6-,7+,8-,9+,10?,13?/m0/s1
• InChIKey=JPFWJDMDPLEUBD-FCQOVDMSSA-N

Synonyms

• 22976-86-9
• Polyoxin D
• Polyoxin D
• Polyoxin-D

Origin

Streptomyces cacaoi var. asoensis

Biological activities

Inhibition of fungal cell wall biosynthesis

Therapeutic

Antifungal

Target

Chitin synthase

Assay information

Inhibition of fungal chitin synthases (K_i = 1.4 μM)
Growth inhibition of some filamentous fungi (plant invaders) (MIC [μg/ml]): P. oryzae (3.12), C.myabiannus (6.25), and P. filamentosa (