FSL0880

Structure

• InChI=1S/C8H15N3O7/c1-11(10-18)8(17)9-4(2-12)6(15)7(16)5(14)3-13/h2,4-7,13-16H,3H2,1H3,(H,9,17)/t4-,5+,6+,7+/m0/s1
• InChIKey=AGRCPNMCOXLKFO-BDVNFPICSA-N

Synonyms

• 18883-66-4
• Streptozocin

Origin

Streptomyces achromogenes

Biological activities

Causing DNA damage

Therapeutic

Antibiotics
Anticancer

Target

DNA
Solute carrier family 2, facilitated glucose transporter member 2

Assay information

Antibiotic activitiy against Salmonella pullorum (IC₅₀ = 0.15 μg/ml), Escherichia coli (IC₅₀ = 0.50 μg/ml) and other organisms
Inhibitor against the growth of mouse lymphoma L1210 cells (IC₅₀ = 75 μg/ml)
Applicabable to generate mouse models of type 1 diabetes or treat pancreatic tumors
Inducer of DNA damage
Selective killer of insulin-secreting pancreatic b cells that express relatively high levels of GLUT2