FSL0686

Structure

• InChI=1S/C36H62O11/c1-10-34(13-14-35(47-34)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40)27-11-12-33(8,44-27)31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40)/t19-,20-,21+,22+,23-,24-,25-,26?,27?,28?,29+,30?,31?,33-,34-,35+,36-/m0/s1
• InChIKey=QVWVPFDISMDSCC-NOCXBAHCSA-N

Synonyms

• 22373-78-0
• Monensin

Origin

Streptomyces cinnamonensis

Biological activities

Ionophore

Therapeutic

Antibacterial
Anticoccidial
Antifungal
Antimalarial

Target

Monovalent cation

Assay information

Inhibitor of ryegrass seed germination and plant growth (10-100 μM)
Inhibitor of Golgi apparatus functions (0.01-1 μM)
Antimalarial activity (IC₅₀ = 1.5 ng/ml)
Antibacterial activity against Gram-positive bacteria (MIC: 0.006-12.5 mg/ml) including VRE and MRAS (MIC: 0.5-16 mg/ml)
Antifungal activity (MIC: 20-100 mg/ml)