FSL0739
- Structure
- InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1
- InChIKey=YJQPYGGHQPGBLI-KGSXXDOSSA-N
- Synonyms
-
- 303-81-1
- Albamix
- Albamycin
- Antibiotic PA-93
- Cardelmycin
- Cathocin
- Cathomycin
- Crystallinic acid
- Inamycin
- MS0A0293
- Novo-R
- Novobiocin
- Novobiocin
- PA 93
- Robiocina
- Sirbiocina
- Spheromycin
- Stilbiocina
- Streptonivicin
- U 6391
- Origin
- Streptomyces niveus
- Biological activities
- Inhibition of DNA replication in bacteria
- Therapeutic
-
Antibacterial
- Target
-
GyrB
ParE
- Assay information
-
Inhibitor of DNA gyrase in E. coli (IC50 = 0.5 μM)
Inhibitor of GryB (IC50 = 0.03 μM) and ParE (IC50 = 1.32 μM)
MIC [μg/ml]: S. aureus (0.125), E. faecalis (8), E. coli (8)