FSL0482

Structure

• InChI=1S/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)
• InChIKey=XDJYMJULXQKGMM-UHFFFAOYSA-N

Synonyms

• 1264-72-8
• 7722-44-3
• Belcomycin
• Colimycin
• Colistin
• Colistin A
• Colymycin
• Polymixin E1
• Polymyxin E1
• Polymyxin-E
• Torazin

Origin

Paenibacillus polymyxa var. colistinus

Biological activities

Disruption of the outer cell membrane of Gram-negative bacilli

Therapeutic

Antibacterial

Target

Bacterial outer cell membrane

Assay information

Binding and neutralizing lipopolysaccharide (LPS) and preventing the pathophysiologic effects of endotoxin in the circulation
Binding to phospholipids in the outer cell membrane of Gram-negative bacteria. Competitively displaces divalent cations from the phosphate groups of membrane lipids, which leads to disruption of the outer cell membrane, leakage of intracell
MICs for susceptible strains, 1 to 4 μg/ml MICs for resisrant strains were >gt;128 μg/ml
Effective antimicrobial effect in vivo using E. coli infected mice at 1 mg/Kg