Bioprobe Application Research Unit (Closed)


Research Scientist
T. Kawamura

Increased levels of cellular reactive oxygen species (ROS) are a common phenotype in many types of cancer cells due to altered metabolism. Since excessive levels of ROS are harmful to cells, modulation of cellular redox homeostasis has attracted attention as a strategy for selective killing of cancer cells. For better understanding and control of redox regulation systems in cancer cells, we have worked on identification and characterization of small-molecule redox modulators.
For further advancement of this project, I worked in Prof. Herbert Waldmann’s research group at the Max Planck Institute (MPI) of Molecular Physiology in Germany. A high throughput screening for small-molecule redox modulators was conducted by using a method which I established in collaboration with researchers at the MPI. Deeper characterization studies on screening hits are ongoing.