isolation and structural determination
Cui CB, Kakeya H, Okada G, Onose R, Ubukata M, Takahashi I, Isono K, Osada H.: Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.
J Antibiot, 48(11): 1382-1384 (1995)
Cui CB, Kakeya H, Okada G, Onose R, Osada H.: Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties.
J Antibiot, 49(6): 527-533 (1996)
Cui CB, Kakeya H, Osada H.: Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures.
J Antibiot, 49(6): 534-540 (1996)
Cui CB, Kakeya H, Osada H.: Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus.
J Antibiot, 49(8): 832-835 (1996)
detailed biological activity
Usui T, Kondoh M, Cui CB, Mayumi T, Osada H.: Tryprostatin A, a specific and novel inhibitor of microtubule assembly.
Biochem J, 333( Pt 3): 543-548 (1998)
Kondoh M, Usui T, Mayumi T, Osada H.: Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ.
J Antibiot, 51(8): 801-804 (1998)
structure-activity relationship
Wang H, Usui T, Osada H, Ganesan A.: Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.
J Med Chem, 43(8): 1577-1585 (2000)
Sanz-Cervera JF, Stocking EM, Usui T, Osada H, Williams RM.: Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro.
Bioorg Med Chem, 8(10): 2407-2415 (2000)