Tautomycetin

Structure
NPEdia Tautomycetin
Producing organism
Streptomyces sp.
Biological activity
protein phosphatase type 1 inhibitor
Abstract
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References
isolation and structural determination
  • Cheng XC, Kihara T, Ying X, Uramoto M, Osada H, Kusakabe H, Wang BN, Kobayashi Y, Ko K, Yamaguchi I.: A new antibiotic, tautomycetin.
    J Antibiot, 42(1): 141-144 (1989) PMID: 2921220
  • Cheng XC, Ubukata M, Isono K.: The structure of tautomycetin, a dialkylmaleic anhydride antibiotic.
    J Antibiot, 43(7): 890-896 (1990) PMID: 2387780
  • biological activity
  • Mitsuhashi S, Matsuura N, Ubukata M, Oikawa H, Shima H, Kikuchi K.: Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
    Biochem Biophys Res Commun, 287(2): 328-331 (2001) PMID: 11554729 [ doi: 10.1006/bbrc.2001.5596 ]
  • Oikawa H.: Synthesis of specific protein phosphatase inhibitors, tautomycin and tautomycetin toward structure-activity relationship study.
    Curr Med Chem, 9(22): 2033-2053 (2002) PMID: 12369869
  • Mitsuhashi S, Shima H, Tanuma N, Matsuura N, Takekawa M, Urano T, Kataoka T, Ubukata M, Kikuchi K.: Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.
    J Biol Chem, 278(1): 82-88 (2003) PMID: 12374792 [ doi: 10.1074/jbc.M208888200 ]