isolation and structural determination
Kobayashi S, Tsuchiya K, Harada T, Nishide M, Kurokawa T, Nakagawa T, Shimada N, Kobayashi K.: Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK10958. I. Taxonomy, production, isolation and preliminary characterization.
J Antibiot, 47(6): 697-702 (1994)
Kobayashi S, Tsuchiya K, Kurokawa T, Nakagawa T, Shimada N, Iitaka Y.: Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK10958. II. Structural elucidation.
J Antibiot, 47(6): 703-707 (1994)
Kobayashi S, Tsuchiya K, Nishide M, Nishikiori T, Nakagawa T, Shimada N.: Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK10958. III. Biosynthesis.
J Antibiot, 48(8): 893-895 (1995)
biological activity as new roles
Kondoh M, Usui T, Kobayashi S, Tsuchiya K, Nishikawa K, Nishikiori T, Mayumi T, Osada H.: Cell cycle arrest and antitumor activity of pironetin and its derivatives.
Cancer Lett, 126(1): 29-32 (1998)
Kondoh M, Usui T, Nishikiori T, Mayumi T, Osada H.: Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin.
Biochem J, 340( Pt 2): 411-416 (1999)
Simizu S, Shibasaki F, Osada H.: Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells.
Jpn J Cancer Res, 91(7): 706-714 (2000)
structure-activity relationship
Watanabe H, Watanabe H, Usui T, Kondoh M, Osada H, Kitahara T.: Synthesis of pironetin and related analogs: studies on structure-activity relationships as tubulin assembly inhibitors.
J Antibiot, 53(5): 540-545 (2000)