isolation and structural determination
Zhang HP, Kakeya H, Osada H.
Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells.
Tetrahedron Letter 38, 1789-1792 (1997) [ doi: 10.1016/S0040-4039(97)00170-6 ]
Kakeya H, Zhang HP, Kobinata K, Onose R, Onozawa C, Kudo T, Osada H.: Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.
J Antibiot, 50(4): 370-372 (1997)
biosynthetic studies
Zhang HP, Kakeya H, Osada H.
Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.
Tetrahedron Letter 39, 6947-6948 (1998) [ doi: 10.1016/S0040-4039(98)01460-9 ]
biological activities
Kakeya H, Onose R, Osada H.: Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
Cancer Res, 58(21): 4888-4894 (1998)
Watabe M, Kakeya H, Onose R, Osada H.: Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis.
J Biol Chem, 275(12): 8766-8771 (2000)