isolation and structural determination
Isono K, Uramoto M, Osada H, Ubukata M, Kusakabe H, Koyama T, Miyata N, Sethi SK, McCloskey JA.: Structure and biological activity of ascamycin, a new nucleoside antibiotic.
Nucleic Acids Symp Ser, (15): 65-67 (1984)
Isono K, Uramoto M, Kusakabe H, Miyata N, Koyama T, Ubukata M, Sethi SK, McCloskey JA.: Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp.
J Antibiot, 37(6): 670-672 (1984)
synthesis
Ubukata M, Osada H, Isono K.: Synthesis and biological activity of nucleoside antibiotics, ascamycin and its amino acid analogs.
Nucleic Acids Symp Ser, (16): 81-83 (1985)
biological activities
Osada H, Isono K.: Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic.
Antimicrob Agents Chemother, 27(2): 230-233 (1985)
Osada H, Isono K.: Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri.
Biochem J, 233(2): 459-463 (1986)
Osada H, Isono K.: Occurrence of an ascamycin dealanylating enzyme, Xc-aminopeptidase, in mammalian cell membranes and susceptibility to ascamycin.
J Antibiot, 39(2): 286-293 (1986)
Sudo T, Shinohara K, Dohmae N, Takio K, Usami R, Horikoshi K, Osada H.: Isolation and characterization of the gene encoding an aminopeptidase involved in the selective toxicity of ascamycin toward Xanthomonas campestris pv. citri.
Biochem J, 319(Pt 1): 99-102 (1996)