Takayuki MOTOYAMA

Takayuki Motoyama
Takayuki MOTOYAMA
(Ph.D,Senior Research Scientist)

INTEREST OF MY RESEARCH

Filamentous fungi (molds) are well known as plant and animal pathogens and mycotoxin producers. On the other hand, filamentous fungi are useful in production of fermentation foods (sake etc.) and medicines. Recently, it has become apparent that huge numbers of secondary metabolism genes of unknown functions are sleeping in the genomes of filamentous fungi. Aims of my research are to develop medicines by using these genes and to develop agrochemicals that control production of fungal secondary metabolites required for pathogenicity.

EDUCATION

1986-1990  The University of Tokyo, Department of Agricultural Chemistry
1990-1996 Graduate Course, The University of Tokyo, Faculty of Agriculture

DEGREES

B.Sc. (1990)  The University of Tokyo 
Dr. Agriculture (1995)  The University of Tokyo 

APPOINTMENTS

1995-2002 Scientist, Microbial Toxicology Lab., RIKEN
2002-2008 Senior Scientist, Environmental Molecular Biology Lab., RIKEN
2008-2015 Senior Scientist, Antibiotics Lab., RIKEN
2014.Feb.-RIKEN Center for Sustainable Resource Science - Chemical Biology Research Group

ACADEMIC ACTIVITIES

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Fungal Molecular Biology Society of Japan
  • Japanese Society for Chemical Biology

MY HOBBY

Appreciation and using of ceramic arts, cat

LIST OF SELECTED PUBLICATIONS

  1. Yun, C.-S, Motoyama, T. amd Osada, H.: "Regulatory mechanism of mycotoxin tenuazonic acid production in Pyricularia oryzae", ACS Chem Biol, 12: 2270-2274 (2017).
    Press release: http://www.riken.jp/pr/press/2017/20171006_1/
  2. Yun, C.-S., Motoyama, T. and Osada, H.: "Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme", Nat Commun, 6: 8758 (2015).
    Press release: http://www.riken.jp/pr/press/2015/20151027_1/
  3. Motoyama, T., Hayashi, T., Hirota, H., Ueki, M. and Osada, H.:" Terpendole E, a Kinesin Eg5 Inhibitor, Is a Key Biosynthetic Intermediate of Indole-Diterpenes in the Producing Fungus Chaunopycnis alba", Chemistry & Biology, 19: 1611-1619, (2012).
    Press release: http://www.riken.jp/pr/press/2012/20121221_2/
  4. Vetcher,, L., Hugo G. Menzella, H.G., Kudo, T., Motoyama, T., and Katz, L.: “
The Antifungal Polyketide Ambruticin Targets the HOG Pathway”, 
Antimicrob. Agents Chemother., 51: 3734-3736 (2007).
  5. Motoyama, T., Ohira, T., Kadokura, K., Ichiishi, A., Fujimura, M., Yamaguchi, I., Kudo, T.: “An Os-1 family histidine kinase from a filamentous fungus confers fungicide-sensitivity to yeast
”, Curr. Genet., 47: 298-306 (2005).