Makoto MUROI

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Makoto MUROI
(Ph.D,Senior Research Scientist)

INTEREST OF MY RESEARCH

Many kind of biological active compounds are isolated from microorganisms, and compounds with new targets provide new insights into biology. I'm interested in the target analysis of such compounds by proteomics.

EDUCATION

DEGREES

APPOINTMENTS

ACADEMIC ACTIVITIES

LIST OF SELECTED PUBLICATIONS

1. Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
   Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.
   Biochim Biophys Acta, (doi: 10.1016/j.bbapap.2018.06.001)
2. Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S.
   Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593.
   ACS Synth Biol 6, 2339-2349 (2017)
3. Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J.
   Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.
   Angew Chem Int Ed Engl 56, 8153-8157 (2017)
4. Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.
   Proteomic profiling reveals that collismycin A is an iron chelator.
   Sci Rep 6, 38385 (2016)
5. Muroi M, Futamura Y, Osada H.
   Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.
   Nat Prod Rep 33, 621-5 (2016)
6. Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
   A small molecule that induces reactive oxygen species via cellular glutathione depletion.
   Biochem J 463, 53-63 (2014)
7. Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H.
   Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.
   Chembiochem 14, 2456-63 (2013)
8. Futamura Y, Muroi M, Osada H.
   Target identification of small molecules based on chemical biology approaches.
   Molecular bioSystems 9, 897-914 (2013)
9. Osada H, Muroi M, Yoshida M.
   The chemistry/biology interface.
   Bioorg Med Chem 20, 1844-1845 (2012)
10. Sasazawa Y, Kanagaki S, Tashiro E, Nogawa T, Muroi M, Kondoh Y, Osada H, Imoto M.
    Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
    ACS Chem Biol 7, 892-900 (2012)
11. Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H.
    Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification.
    Chem Biol 19, 1620-1630 (2012).
12. Asami Y, Jang JH, Soung NK, He L, Moon DO, Kim JW, Oh H, Muroi M, Osada H, Kim BY, Ahn JS.
    Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells.
    Bioorg Med Chem 20, 3799-3806 (2012)
13. Jang JH, Asami Y, Jang JP, Kim SO, Moon DO, Shin KS, Hashizume D, Muroi M, Saito T, Oh H, Kim BY, Osada H, Ahn JS.
    Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326.
    J Am Chem Soc 133, 6865-6867 (2011)
14. Kawatani M, Takayama H, Muroi M, Kimura S, Maekawa T, Osada H.
    Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.
    Chem Biol 18, 743-751 (2011).
15. Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, Usui T, Osada H.
    Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.
    Chem Biol 17, 460-470 (2010)